Home exercise program to improve thinking problems after brain tumor treatment

Plain-English translation of NCT06799481 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether a 12-week home exercise program called RISE can help young adults (ages 15–39) who experienced thinking and memory problems after brain tumor radiation therapy. The program combines aerobic exercise, strength training, and coaching delivered through a smartphone app. Researchers want to see if exercise can improve cognitive problems and also affect the beneficial bacteria in your gut.

Many young adults who survive brain tumors and radiation therapy experience lasting problems with thinking, memory, and focus that can affect their daily lives and opportunities. This study exists to see whether exercise—a safe, accessible intervention—might help restore some of these cognitive abilities and improve overall quality of life.

Do you qualify?

You likely qualify if…

you are between 15 and 39 years old
you had a primary brain tumor treated with cranial radiation therapy
you are between 6 months and 4 years past your radiation treatment
you are experiencing thinking or memory problems since your treatment
you are currently doing less than 150 minutes of physical activity per week
you have permission from your doctor to participate in exercise and can use a smartphone app

You likely don't qualify if…

you have had cancer return or are being treated with additional brain radiation
you have a serious brain injury beyond what was caused by your tumor and its treatment
you have autism, schizophrenia, or severe depression that might affect study results
you are unable to walk or have medical conditions that prevent safe exercise

What participation looks like

If you join this study, you'll be randomly assigned to either the exercise program or a comparison group. If you're in the exercise group, you'll use a smartphone app called Physitrack to do 30–40 minutes of aerobic exercise 3–5 days per week and strength training 2 days per week, plus receive brief coaching calls from a trainer. The comparison group will receive weekly check-in calls and wear a fitness tracker. The active program lasts 12 weeks, with a follow-up visit 6 weeks later to see how you're doing.

Home exercise program to improve thinking problems after brain tumor treatment

What is this trial?

Do you qualify?

What participation looks like

Trial locations(2 sites)