Plain-English translation of NCT06805994 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This study is testing a procedure called a to help babies restore healthy bacteria in their noses. Infants in the hospital who have been treated with nasal antibiotic cream for a staph infection will receive either one or multiple applications of bacteria swabbed from a parent's nose, or a placebo (sterile swab with no bacteria). The goal is to see if this treatment helps reestablish a healthy and diverse community of bacteria in the baby's nose.
Antibiotic treatments kill harmful bacteria but can also remove the helpful bacteria that normally live in the nose. This study explores whether transferring healthy bacteria from a parent can help the baby's nose recover its natural protective bacteria faster and more completely.
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If your child is enrolled, a healthy parent or family member will be screened to ensure they are free of harmful bacteria and respiratory infections. At the time of the procedure, a sterile swab will be used to collect bacteria from the parent's nose, and then that same swab (or a sterile placebo swab) will be gently inserted into your child's nose. Your child will be monitored during the hospital stay, and follow-up nasal samples may be collected to track whether the treatment helps restore healthy bacteria.
AI-generated summary from trial data · Sep 24, 2026 · Not medical advice
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