Plain-English translation of NCT06807307 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are studying the genes and gene interactions in lung cancer tumors to understand why some patients respond well to immunotherapy while others don't. By analyzing tissue samples collected before treatment begins, the study aims to identify specific genetic patterns that can predict which patients will benefit most from immunotherapy. This knowledge could help doctors personalize treatment choices for future lung cancer patients.
Currently, doctors don't have reliable ways to predict before starting treatment whether a patient's cancer will respond to immunotherapy. This trial exists to find genetic markers that could help identify responders in advance, potentially sparing patients from ineffective treatments and helping them access therapies more likely to work for their specific tumor.
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If you join this study, researchers will use your existing tumor tissue samples (already collected during surgery or biopsy) along with your medical records to analyze your cancer's genes. You will be part of either a retrospective group (samples from 2017–2021) or a prospective group (newly enrolled patients). The study involves no new procedures or medications — it's purely an analysis of samples you've already had collected, combined with tracking your response to your standard immunotherapy treatment over time.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
Italy
Regina Elena Cancer Institute
Enrollment target
~256 participants
Started
June 2024
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Marcello Maugeri Saccà, Medical Doctor
Regina Elena Cancer Institute
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.