Recruiting

Testing a medication to prevent a surgical complication after pancreas surgery

Plain-English translation of NCT06807437 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing whether a medication called can help prevent a serious complication after pancreatic cancer surgery. When surgeons remove part of the pancreas, there's a risk that fluid can leak from the pancreas into the belly — a problem called a pancreatic fistula. Researchers want to see if giving before surgery can reduce this risk and help people recover better.

Pancreatic fistula is a common and serious complication after pancreatic surgery that can lead to longer hospital stays, infections, and other problems. This medication has been used to treat other pancreatic conditions, and doctors believe it might help prevent this surgical complication, but it hasn't been thoroughly tested for this specific purpose yet.

Do you qualify?

You likely qualify if…

you have been diagnosed with pancreatic cancer or a suspicious pancreatic lesion confirmed by biopsy or imaging
you are scheduled to have surgery to remove part of your pancreas within 60 days of enrolling
you are 18 years or older
you have not received similar medications (somatostatin analogues) in the past 6 months
you have not had radiation therapy to your pancreas
your kidney function is normal or only mildly decreased

You likely don't qualify if…

you have a history of malabsorption syndrome (difficulty absorbing nutrients)
you have been treated with radiation therapy for pancreatic cancer
you have severe liver disease with very high liver enzyme levels
you require more extensive surgery than just removing part of the pancreas (such as removing nearby organs)
you are currently taking certain medications that interact significantly with lanreotide without a plan to monitor and adjust doses

What participation looks like

If you enroll, you'll receive either the medication or a placebo injection within 36 hours before your scheduled pancreas surgery. You'll have blood drawn right before surgery and on days 1 and 3 after surgery, and your doctors may also collect fluid from around the pancreas area on those same days. After surgery, the research team will follow you for 60 days to monitor for complications and check on your recovery, including your hospital stay length and how you're feeling using quality-of-life questionnaires.

AI-generated summary from trial data · Jun 10, 2026 · Not medical advice

Testing a medication to prevent a surgical complication after pancreas surgery

What is this trial?

Do you qualify?

What participation looks like

Trial locations(118 sites)