Plain-English translation of NCT06808230 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Migraine research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This is a pilot study testing cocoa extract as a potential migraine prevention tool. Researchers want to see if people with episodic migraines will take cocoa extract supplements daily and whether different doses are acceptable and tolerable. The study will compare a higher dose, a lower dose, and a placebo (inactive pill) to understand how well this treatment works for migraine sufferers.
Migraines affect millions of people and many are looking for effective prevention strategies beyond current medications. This medication may offer a natural supplement option, but researchers first need to confirm that people can stick with it and that it's safe before testing whether it actually reduces migraine frequency.
You likely qualify if…
You likely don't qualify if…
You would take four pills by mouth every day for 12 weeks—either all placebo, a mix of cocoa extract and placebo, or all cocoa extract, depending on which group you're assigned to. You'll also complete daily questionnaires on your phone, provide two urine samples, and keep a headache diary. The entire study lasts about 4 months from start to finish.
AI-generated summary from trial data · Jul 10, 2026 · Not medical advice
United States
Sponsor
Brigham and Women's Hospital
Collaborators
National Center for Complementary and Integrative Health (NCCIH)
Enrollment target
~114 participants
Started
June 2025
Primary completion
December 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in June 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Pamela M Rist, ScD
Brigham and Women's Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.