Testing a new injection to reduce heart plaque buildup

Plain-English translation of NCT06813339 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated July 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This is an early-stage trial testing a new medication called designed to treat heart disease caused by plaque buildup in blood vessels. The study will first give the medication to healthy volunteers in increasing doses to make sure it's safe, and then test it in people who have experienced a heart attack or unstable angina within the past year. Researchers want to understand how the medication works in the body and whether it can help reduce the plaque that damages the heart.

Current treatments for heart disease caused by plaque buildup don't always work well enough, and doctors need safer, more effective options. This study aims to see if this new medication could be a better way to help patients reduce dangerous plaque in their arteries.

Do you qualify?

You likely qualify if…

you are 18 to 65 years old (if you are a healthy volunteer) or 40 to 79 years old (if you have had a heart attack or angina)
you are willing to receive injections of either the new medication or a placebo (inactive substance)
you are able to follow the study schedule and complete all required visits and health checks
you have had a diagnosis of acute coronary syndrome (a heart attack or unstable angina) at least 12 months ago (if joining the patient group)
your kidneys, liver, and heart are working well based on recent medical tests

You likely don't qualify if…

you smoke or use nicotine products (you must have quit at least 2 weeks before starting)
you have significant kidney or liver problems
you have changed your heart medications in the past 3 months (for the patient group)
you are pregnant or breastfeeding
you have any serious health condition that your doctor thinks would make the study unsafe for you

What participation looks like

If you're a healthy volunteer, you'll receive a single injection or multiple injections over 16 days, with visits for blood tests and heart monitoring. If you have heart disease, you'll receive 6 injections over 6 weeks and have regular check-ups to monitor your heart health and plaque levels. All participants will have their blood drawn and heart function checked at scheduled visits to track how the medication affects their body.

Testing a new injection to reduce heart plaque buildup

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)