Therapy to Reduce Fear of Cancer Return in BRCA Gene Carriers

Plain-English translation of NCT06817694 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a short therapy program called cognitive behavioral therapy (CBT) designed to help women with BRCA1 or BRCA2 gene mutations manage their fear that their cancer might come back. The program consists of four sessions, each about 2 hours long, and is delivered in a group setting. Researchers want to see how well this therapy works when offered as part of regular cancer care.

Many cancer survivors—especially those with BRCA gene mutations—experience ongoing fear that their cancer will return, which can affect their quality of life and mental health. While this therapy program has shown promise in earlier studies, researchers want to test it more rigorously to confirm it truly helps patients and to understand how best to offer it to people who need it.

Do you qualify?

You likely qualify if…

you have finished your main cancer treatment (surgery, chemotherapy, and/or radiation) for breast or ovarian cancer
you carry a BRCA1 or BRCA2 gene mutation
you experience moderate to severe worry about your cancer returning
you are at least 18 years old
you can read, speak, and understand French

You likely don't qualify if…

your cancer has spread to distant parts of your body (or in ovarian cancer, you have stage IIIC or stage IV disease)
you have a known cognitive disorder that would affect your ability to participate
you have a severe mental health condition such as a psychotic disorder, bipolar disorder, or active substance abuse
you already participated in this same therapy program at the Quebec hospital where the study is based

What participation looks like

You will be randomly assigned to either start the therapy program right away or wait 7 weeks before starting. The therapy program consists of four group sessions, each lasting about 2 hours, where you and other women with similar concerns will learn and practice techniques to manage fear of recurrence. The sessions are conducted by trained therapists and include both educational materials and practical exercises you can use at home.

Therapy to Reduce Fear of Cancer Return in BRCA Gene Carriers

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)