Plain-English translation of NCT06822543 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Lung Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination of three medications — , , and — given together to treat non-small cell lung cancer that has spread to the brain. Researchers want to see if this combination can shrink tumors and help people live longer. The study will enroll 46 people across multiple centers in Latin America.
Brain metastases from lung cancer are serious and difficult to treat, and many patients do not have good options. This trial is exploring whether combining this newer targeted therapy with standard chemotherapy and an immunotherapy drug can work better for people whose cancer has already reached the brain.
You likely qualify if…
You likely don't qualify if…
You would receive intravenous infusions of the three medications every three weeks for four initial treatment cycles, then continue on maintenance therapy with two of the medications until the cancer progresses or side effects become unacceptable. You would visit the clinic every three weeks for blood tests and medical evaluations, and have imaging scans (CT and brain MRI) done every 6 weeks for the first 6 months, then every 9 weeks after that. You would also complete quality-of-life questionnaires to help researchers understand how the treatment affects your daily life.
AI-generated summary from trial data · Jul 6, 2026 · Not medical advice
Brazil