Exercise training program for sickle cell disease patients

This trial is testing whether a carefully designed exercise training program can help people with sickle cell disease build strength and endurance over time. Sickle cell disease makes everyday physical activity very difficult because the disease reduces oxygen delivery to muscles and causes severe fatigue. Researchers want to see if gradual, supervised exercise can safely improve how far patients can walk, how they feel day-to-day, and their overall quality of life.

People with sickle cell disease often struggle with even simple physical tasks like walking short distances, and there is very little guidance on safe ways to build fitness for this population. This study aims to fill that gap by testing whether a structured exercise program—delivered either in a hospital setting first or entirely at home—can safely improve fitness and reduce the burden of living with this disease.