Testing a new medication for advanced colorectal cancer that has stopped responding to standard treatments

This study is testing a new medication called RBS2418 to see if it can help people with advanced colorectal cancer that has stopped responding to standard treatments. You would take the medication twice daily by mouth, along with your regular supportive care, for up to two years or until your disease worsens. The study will compare this treatment to a placebo (a pill with no active medication) to understand whether the medication truly helps.

People with advanced colorectal cancer that has progressed despite all available standard treatments have very limited options. Researchers are testing this medication because early signs suggest it may help some patients, especially those whose cancer cells have specific genetic markers.