Plain-English translation of NCT06825104 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Atrial Fibrillation research guide →This is a follow-up study for patients who already participated in a previous trial testing two different ways to treat persistent atrial fibrillation (a common heart rhythm problem). Some patients received a tailored ablation procedure guided by artificial intelligence software that identifies problem areas in the heart, combined with standard pulmonary vein isolation. Others received the standard approach alone. This new study will track both groups over five years to see which approach provides longer-lasting benefits.
The initial trial showed that the AI-guided tailored approach worked better after one year, but doctors need to know if these benefits last over time. This longer follow-up will help determine whether the advanced technique provides sustained improvement compared to standard care.
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If you're eligible, you'll continue the follow-up visits you were already having — visiting your doctor annually at 2, 3, 4, and 5 years after your original ablation procedure. At each visit, you'll wear a small heart monitoring device for 24 hours and complete quality-of-life questionnaires. If you need another ablation procedure during the study, your doctor will decide which approach is best for you. The study is designed to fit into routine heart care, so it won't require extra time or burden beyond standard follow-up.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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