Plain-English translation of NCT06826755 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is testing melatonin — a natural hormone supplement — to see if it can help protect heart health in midlife women who have high blood pressure and are experiencing menopause. You would take either melatonin or a placebo (a harmless sugar pill that looks identical) once daily before bed for 12 weeks. The researchers want to understand whether this medication might help reduce the cardiovascular risk that sometimes increases during menopause.
Many women experience increases in blood pressure and other heart-related changes during midlife and menopause, which can raise their risk of heart disease. This medication is already used safely by many people, but researchers want to learn specifically whether it can help protect the hearts of women going through this life stage.
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You would take one capsule by mouth once daily about one hour before bed for 12 weeks — either the melatonin or placebo, and neither you nor the researchers will know which one you're taking at first. The study involves visits to Mayo Clinic where researchers will measure your blood pressure, heart function, and other cardiovascular health markers to compare how your heart responds to the treatment versus placebo over those 12 weeks.
AI-generated summary from trial data · Aug 27, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Enrollment target
~70 participants
Started
May 2025
Primary completion
September 2027
Age range
40 Years – 55 Years
Sex
Female only
Last updated on clinicaltrials.gov in August 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Perimenopause Study Team
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.