Plain-English translation of NCT06827236 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a new breast cancer treatment called combined with another medication called . Researchers want to find the best dose of this two-drug combination and learn whether it is safe and works well for people with advanced breast cancer. The study will first test different dose levels to find the safest and most effective combination, then test that combination against other treatment approaches.
Advanced breast cancer that has spread to other parts of the body or cannot be removed with surgery is difficult to treat, and many patients need new treatment options. This medication represents a new approach that researchers believe could help control the disease better while managing side effects.
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The study has two phases: in the first phase, small groups of participants receive gradually increasing doses of the two-drug combination to find the safest dose. In the second phase, more participants receive the best dose found in phase one, and some are randomly assigned to receive either the combination treatment, one drug alone, or the other drug alone. Participants will have regular visits for blood tests, scans, and checkups to monitor how well the treatment works and watch for side effects. The study involves about 380 participants across multiple hospital sites.
AI-generated summary from trial data · Aug 4, 2026 · Not medical advice
United States