Plain-English translation of NCT06831500 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing whether adjusting the ratio of carbidopa to levodopa in Parkinson disease and multiple system atrophy medication can reduce orthostatic hypotension—a sudden drop in blood pressure when you stand up that causes dizziness, lightheadedness, or fainting. You'll take three different ratios of the medication at separate visits so researchers can measure how each one affects your blood pressure and symptoms.
Doctors know that the medication used to treat Parkinson symptoms can make blood pressure drops worse, but they don't yet understand which ingredient—the levodopa or the carbidopa—is responsible. This study aims to find out whether changing the balance between these two ingredients could help reduce this side effect and improve your quality of life.
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You will visit the research clinic three times over several weeks. At each visit, you'll stop taking your regular Parkinson medication overnight, then take a single dose of the study medication at a different ratio each time. The researchers will measure your blood pressure, monitor your symptoms, and ask you questions about dizziness or lightheadedness to see how each ratio affects you.
AI-generated summary from trial data · Aug 22, 2026 · Not medical advice
Switzerland