Recruiting

Testing a cream treatment for moderate eczema in young people

Plain-English translation of NCT06832618 on ClinicalTrials.gov ↗ · Source last updated December 2025 · Translation generated June 2026 · How we translate trials

Read our Atopic Dermatitis research guide →

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This study is testing whether a medication called cream works safely and effectively to treat moderate atopic dermatitis (eczema) in children and teenagers. Half the participants will receive the real medication twice daily, and half will receive a look-alike cream without active medicine. The study will measure how much the treatment helps reduce itching, redness, and skin involvement over time.

Current treatments for moderate eczema—like topical steroids and other prescription creams—don't work well enough for some young people, or cause side effects they can't tolerate. This trial is testing whether this new treatment approach can offer a better option for kids and teens whose eczema hasn't responded well to existing therapies.

Do you qualify?

You likely qualify if…

you are between 6 and 17 years old
you have been diagnosed with atopic dermatitis (eczema) for at least 3 months (if under 12) or 2 years (if 12 or older)
your eczema affects at least 3% but no more than 20% of your skin surface
your eczema causes significant itching and has not responded well to, or you cannot tolerate, topical steroid creams or other standard prescription treatments tried in the past year
you are willing to stop using other eczema treatments during the study (except as the study allows)

You likely don't qualify if…

you are pregnant or nursing, or unwilling to use contraception if sexually active
you have a documented serious allergic reaction to any ingredient in the study medication
you are currently taking or have recently taken certain systemic medications for eczema without an adequate washout period
you have an active skin infection or other skin condition that would interfere with evaluating the study medication

What participation looks like

You would apply the study cream to your skin twice daily during an initial phase, then move to twice-weekly applications if your eczema improves. You'll visit the clinic multiple times to have your skin checked, answer questions about itching and discomfort, and report any side effects. The study includes both a blinded phase (where you don't know if you're getting the real medication or the look-alike cream) and a longer open-label extension where everyone receives the active treatment.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Trial locations(96 sites)

United States

Clinical Research Center of Alabama, Birmingham, Alabama

Saguaro Dermatology, Phoenix, Arizona

National Jewish Health, Denver, Colorado

Encore Medical Research, Llc Hollywood, Hollywood, Florida

Lane Dermatology and Dermatologic Surgery, Columbus, Georgia