Adaptive radiation therapy for prostate cancer with urinary symptoms

Plain-English translation of NCT06834152 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

What is this trial?

This trial is testing stereotactic body radiotherapy (SBRT)—a specialized form of radiation therapy that delivers high doses of radiation very precisely to the prostate cancer in just five weekly treatments. The study focuses on men with prostate cancer who also have urinary symptoms or an enlarged prostate, groups for whom this treatment may have been thought risky in the past. Researchers want to show that this faster treatment is safe and effective for these patients.

Standard radiation therapy for prostate cancer typically takes 8 to 9 weeks. This newer, faster treatment can be done in just one week, which is appealing—but doctors have worried it might cause more urinary side effects in men who already have trouble urinating or have an enlarged prostate. This trial aims to prove that the treatment is actually safe enough for these patients.

Do you qualify?

You likely qualify if…

you have been diagnosed with localized prostate cancer (confirmed by biopsy)
your prostate is enlarged (larger than 60 cubic centimeters) and/or you have moderate to severe urinary symptoms
your cancer is intermediate to very high risk according to standard classification systems
you are willing to receive five weeks of weekly radiation treatments with imaging guidance
you do not have cancer that has spread beyond the prostate or seminal vesicles

You likely don't qualify if…

you have had previous radiation therapy to your pelvis or prostate
you have inflammatory bowel disease or other conditions that make radiation risky
you have severe urinary retention (inability to urinate) or other very severe urinary problems
you have cancer that has spread to lymph nodes or distant parts of your body
you cannot safely have CT or MRI imaging

What participation looks like

You will receive five radiation treatments, one per week, each guided by imaging (either CT or MRI scans taken the same day) to track your prostate's exact position. Before and after treatment, you will have follow-up visits where doctors monitor your urinary symptoms and watch for any side effects. The entire treatment course takes about five weeks, and then you will continue with regular check-ups to monitor your cancer and any late effects.

AI-generated summary from trial data · Jul 7, 2026 · Not medical advice

Trial locations(3 sites)

Germany

Klinik für Radioonkologie und Strahlentherapie, Universitätsklinikum Heidelberg, Heidelberg, Baden-Wurttemberg

Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Universitätsklinikum LMU, Munich, Bavaria

Switzerland

University Hospital Zurich, Department of Radio-Oncology, Zurich, Canton of Zurich