Plain-English translation of NCT06835556 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research trial is testing whether a type of therapy called CBTp (cognitive behavioral therapy for psychosis) can help reduce paranoid beliefs in people with schizophrenia-spectrum disorders. The researchers want to understand whether effective treatment changes how people learn to assess threats and how their brains respond to uncertainty. This is basic science research focused on understanding the brain mechanisms behind paranoia.
People with schizophrenia often experience strong, persistent beliefs that others are trying to harm them, which causes real suffering. Doctors have treatments that help, but researchers don't fully understand how these treatments work or what changes in the brain when paranoid beliefs improve. This study aims to fill that gap so future treatments can be more effective.
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You will be randomly assigned to one of two groups. One group receives specialized therapy sessions once a week for 16 weeks, tailored to address your specific paranoid beliefs and the thoughts that maintain them. The other group continues with your regular care and receives brief weekly phone check-ins from a study therapist. Either way, you'll complete assessments about your symptoms at four different times over six months, and if possible, you may have an MRI scan to look at brain activity. The entire study lasts about six months.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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