Plain-English translation of NCT06845046 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether adding omega-3 fatty acids and L-carnitine supplements to a heart-healthy diet can help veterans with HIV build better-quality muscle and reduce excess fat stored inside muscle tissue. Many veterans with HIV develop a condition where fat accumulates within their muscles, which can lead to weakness, frailty, and diseases like diabetes and heart disease. This study aims to find out if these supplements, combined with dietary changes, can reverse that problem.
Veterans with HIV are living longer thanks to modern HIV medications, but many now struggle with obesity and a special type of muscle damage where fat builds up inside muscle fibers. This excess fat in muscle is linked to poor physical function, disability, and serious health conditions — yet there are few proven treatments for it. This trial seeks to test whether these affordable, natural supplements can help solve this overlooked problem.
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You would be randomly assigned to one of four groups: a control diet group, or one of three groups receiving the same healthy diet plus either omega-3 supplements, L-carnitine, or both supplements together. Over the course of the study, you would have visits where researchers measure your muscle quality using imaging scans, perform physical function tests, and take blood samples. You would also follow your assigned diet and take your supplements (or placebo) as directed.
AI-generated summary from trial data · Jun 26, 2026 · Not medical advice
United States