Recruiting

Testing a new injection for binge eating and weight management

Plain-English translation of NCT06847399 on ClinicalTrials.gov ↗ · Source last updated September 2025 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This clinical trial is testing a medication called to see if it can help people with binge eating disorder and obesity. is given as a weekly injection. You'll be randomly assigned to receive either the medication, a comparison medication, or a placebo (inactive treatment), and all participants will also receive therapy support to help with eating behaviors.

Binge eating disorder is a serious condition that affects many people, and current treatment options are limited. This study aims to see if this medication can reduce binge eating episodes and support healthy weight management better than existing options.

Do you qualify?

You likely qualify if…

you are 18 years of age or older
you have been diagnosed with binge eating disorder (at least 4 binge episodes per week) confirmed by medical interview
you have a BMI of 30 or higher (or 27 or higher with an obesity-related health condition)
you have tried unsuccessfully to lose weight through diet before
you are willing to learn to self-inject medication or receive injections from a trained person
if you can become pregnant, you agree to use two forms of birth control during the study

You likely don't qualify if…

you have been diagnosed with bulimia nervosa or anorexia nervosa
you have type 1 or type 2 diabetes, or a history of diabetic complications
you are currently pregnant, breastfeeding, or planning to become pregnant during the study
you are unable or unwilling to self-inject medication or take daily oral capsules

What participation looks like

If you join this study, you will receive either a weekly injection of the new medication, a comparison medication, or a placebo—along with guided therapy sessions to help with binge eating behaviors. You'll attend regular study visits to report your progress, have your weight monitored, and complete interviews about your eating patterns. The study involves learning to self-inject (or receiving injections from a trained staff member if you cannot inject yourself) and taking daily oral capsules as directed.

AI-generated summary from trial data · Jun 14, 2026 · Not medical advice

Trial locations(1 site)

United States

Johns Hopkins University, Baltimore, Maryland