Testing a new procedure for severe migraines that don't respond to other treatments

This trial is testing a procedure called middle meningeal artery embolization using special non-adhesive materials (SQUID 12 and SQUID 18) to treat people with chronic migraines that haven't responded to other treatments. The procedure involves carefully threading a catheter to a specific blood vessel in the head and filling it with these materials to reduce migraine symptoms. Researchers want to see whether this treatment is safe and actually reduces how often and severely migraines occur.

Many people with chronic migraines continue to suffer even after trying multiple medications and other therapies. This trial exists because doctors are looking for new options for patients whose migraines are resistant to standard treatments, and early research suggests that targeting a specific blood vessel may help.