Plain-English translation of NCT06853145 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This early-phase study is testing whether hyperpolarized xenon-129 MRI—a new type of imaging scan—can safely and reliably measure blood flow and air movement in the lungs of people with idiopathic pulmonary fibrosis (IPF). The scan uses a special form of xenon gas combined with standard MRI technology. Researchers hope this new imaging method could eventually help doctors track how IPF progresses and how well treatments are working, without waiting months or years for traditional lung function tests.
People with IPF currently have limited treatment options, and the standard ways to measure whether treatments are working—like lung function tests done over months—are slow and don't always capture what matters most to patients. A faster, more detailed imaging method could help doctors spot changes earlier and test new treatments more efficiently.
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If you join this study, you will undergo a hyperpolarized xenon-129 MRI scan at the University of Virginia. During the scan, you will breathe in a special form of xenon gas and then lie still in the MRI machine for about 10–15 seconds while images are taken. The scan itself is non-invasive and does not involve radiation. The study is small (enrolling about 6 people total) and is designed to test whether this new imaging method is feasible and safe to use in people with IPF.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
University of Virginia
Enrollment target
~6 participants
Started
May 2025
Primary completion
December 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2025.
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Central contact
Roselove Asare, MA
University of Virginia
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