Testing safer bowel surgery for Crohn's disease patients on biotherapy

This is a safety and effectiveness trial for patients with Crohn's disease who need surgery to remove part of their bowel. Researchers are testing a modified surgical technique that removes more of the affected tissue (including the mesentery, a membrane that supports the bowel) compared to standard surgery. The goal is to see if this approach is safe when patients are already receiving biotherapy (modern immune-suppressing medications).

Many Crohn's disease patients eventually need surgery, but disease often comes back quickly after standard surgery—affecting up to 80% of patients within a year. Early research suggests that removing more affected tissue during the original surgery might reduce these returns by more than 30%, so researchers want to confirm this works safely alongside the biotherapy treatments patients are already taking.