Plain-English translation of NCT06856252 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers are creating tiny three-dimensional models of liver tissue in the laboratory using samples from patients undergoing liver procedures. They want to understand how a specific gene variation (called I148M in the PNPLA3 gene) affects whether someone develops non-alcoholic fatty liver disease (NASH), a serious condition where fat builds up in the liver.
Non-alcoholic fatty liver disease affects about one in three people, and some develop a more severe form called NASH that can lead to cirrhosis or liver cancer. Scientists have discovered that genetics play a major role in who gets sicker, but they need to better understand exactly how these genetic differences cause the disease so they can develop better treatments and predict who is at highest risk.
You likely qualify if…
You likely don't qualify if…
If you qualify, you would donate a small sample of liver tissue during a procedure you are already scheduled to have (such as a biopsy or surgery). You would also provide blood samples and allow researchers to access your medical records and genetic information. The actual tissue sample comes from tissue that would otherwise be discarded, so there is no additional surgery or procedure required specifically for this study.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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