Plain-English translation of NCT06857006 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether radiation therapy for brain metastases (tumors that have spread to the brain) works better with smaller or standard safety margins. When doctors treat multiple brain tumors with radiation in a single session, they add extra space around each tumor to account for potential errors in positioning. This study compares a no-margin approach versus a 2-millimeter margin approach to see which gives patients better tumor control while causing fewer side effects.
Right now, most radiation centers worldwide add safety margins when treating multiple brain tumors at once, but doctors aren't sure if these margins actually help patients or if they just expose more healthy brain tissue to radiation and increase the risk of damage. This trial will help establish the best standard approach for this type of treatment.
You likely qualify if…
You likely don't qualify if…
You will have two radiation treatment plans created for you—one using no margin and one using a 2-millimeter margin around your tumors. Your radiation oncologist will decide which plan is best for your specific situation based on your tumor size and location. The radiation dose will depend on the size of your largest tumor and typically involves either a single treatment session or three treatment sessions over time. Your team will monitor you afterward to track how well the treatment worked and whether you experience any side effects.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
United States
Sponsor
University of Alabama at Birmingham
Enrollment target
~180 participants
Started
April 2025
Primary completion
June 2028
Age range
19 Years and older
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
John Fiveash, MD
The University of Alabama at Birmingham
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.