Plain-English translation of NCT06857123 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether taking longer rest breaks during exercise sessions makes a difference for people with knee osteoarthritis. You'll do a 12-week exercise program three times a week, and researchers will compare two groups: one that exercises with standard short breaks, and another with two 45-minute rest periods built into each session. The study will measure changes in your knee health using imaging, strength tests, and blood samples.
Doctors want to find the best way to design exercise programs for people with knee arthritis—specifically, whether giving your cartilage time to recover during workouts might reduce pain and improve how well your knee works over time.
You likely qualify if…
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You'll come in three times a week for 12 weeks to exercise in a controlled setting. Each session lasts about two and a half hours and includes a warm-up, muscle-strengthening exercises for your legs, and treadmill walking. Before and after the program, you'll have tests done: MRI scans of your knees, walking analysis, strength testing, and blood and joint fluid samples. You'll also complete some questionnaires about how you're feeling.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
United States
Sponsor
University of Pittsburgh
Collaborators
Carnegie Mellon University
Enrollment target
~20 participants
Started
December 2024
Primary completion
December 2026
Age range
45 Years – 79 Years
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Gaupp
University of Pittsburgh
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.