New cell therapy combined with chemotherapy for advanced pancreatic cancer

Plain-English translation of NCT06861452 on ClinicalTrials.gov ↗ · Source last updated December 2025 · Translation generated June 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing a completely new approach to treat locally advanced pancreatic cancer. Researchers have developed , a treatment made from your own fat cells that are genetically modified to help your immune system fight cancer. In this study, you would first receive two cycles of standard chemotherapy drugs, and then receive an injection of directly into the tumor.

Most people with advanced pancreatic cancer cannot have surgery to remove the tumor, which is currently the only treatment that might cure it. This trial exists to find new ways to shrink these tumors and help more patients become eligible for surgery, potentially offering them a chance at cure.

Do you qualify?

You likely qualify if…

you have been diagnosed with locally advanced pancreatic adenocarcinoma that cannot be surgically removed
your cancer has not spread to other parts of your body
your tumor can be seen on imaging and measured
you are healthy enough to receive chemotherapy treatment
you are willing to have a liposuction procedure to collect fat cells for the treatment

You likely don't qualify if…

you have received chemotherapy or radiation therapy for pancreatic cancer before
you have a weakened immune system or a history of serious infections including HIV or hepatitis
you have severe heart disease or had a heart attack in the past year
you have active cancer elsewhere in your body (other than your pancreas)
you are allergic to fluoroquinolone antibiotics or protamine sulfate

What participation looks like

You would receive two cycles of standard chemotherapy drugs given intravenously on specific days over about two months. After completing the chemotherapy, you would undergo a liposuction procedure to collect fat tissue from your body. Your fat cells would then be sent to a laboratory to be genetically modified into the treatment cells. Finally, a doctor would inject the modified cells directly into your pancreatic tumor using ultrasound guidance. Throughout the study, you would have regular visits for blood tests, imaging scans, and monitoring of how you're responding to treatment.

AI-generated summary from trial data · Jun 15, 2026 · Not medical advice

Trial locations(1 site)

Italy

Azienda Ospedaliero-Universitaria (AOU) Policlinico di Modena, Modena, Italy