HPV Vaccination and Multiple Infections in Cervical Dysplasia

Plain-English translation of NCT06862102 on ClinicalTrials.gov ↗ · Source last updated March 2025 · Translation generated June 2026 · How we translate trials

What is this trial?

This research study is looking at how HPV vaccination may help people who have cervical cell changes caused by multiple types of human papillomavirus (HPV) infection. Researchers want to understand whether vaccination can reduce the risk of these changes becoming more serious, and how different HPV types interact with each other in the body. The study will compare people who receive the vaccine with those who don't to see if there are differences in how their cervical health progresses.

Doctors have noticed that people with multiple HPV infections at once tend to have more serious cervical cell changes than those with just one type. This study exists to understand whether vaccination might help protect people who already have multiple HPV infections, and whether the vaccine could slow or prevent the progression to more severe disease.

Do you qualify?

You likely qualify if…

you have abnormal cervical cells detected on a Pap smear that need further evaluation
you have tested positive for HPV infection
you have been diagnosed with cervical intraepithelial neoplasia (CIN) confirmed by biopsy
you are 18 years of age or older
you have HPV-related skin lesions on the vagina, vulva, or cervix

You likely don't qualify if…

you are currently pregnant
you are under 18 years old
you have had treatment for HPV-related lesions in the past 5 years
you have been diagnosed with invasive cervical cancer at stage 1B or higher

What participation looks like

Participants in this study will either receive HPV vaccination or be in a comparison group that does not receive the vaccine. Both groups will be followed over time with regular cervical exams and testing to monitor how their condition changes. Researchers will collect tissue samples and track whether vaccination affects the presence of multiple HPV infections and the progression of cervical cell changes.

AI-generated summary from trial data · Jun 7, 2026 · Not medical advice

Trial locations(1 site)

Italy

Fondazione IRCCS Policlinico San Matteo, SC Ostetricia e Ginecologia 1, Pavia, Pavia

Key details

Sponsor

Fondazione IRCCS Policlinico San Matteo di Pavia

Enrollment target

~152 participants

Started

January 2021

Primary completion

February 2026

This trial's estimated completion date has passed — the record may not be fully up to date.

Age range

18 Years and older

Sex

Female only

Last updated on clinicaltrials.gov in March 2025.

Contact the research team directly

Reach out to the team running this trial. Response times vary — some teams are faster than others.

Central contact

Barbara Gardella, Principal investigator

Fondazione IRCCS Policlinico San Matteo di Pavia

Interested in joining?

Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.

View full record on ClinicalTrials.gov