Plain-English translation of NCT06862115 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether patients with high blood pressure should stop or continue taking their ACE inhibitors or ARBs (common blood pressure medications) before undergoing colorectal cancer surgery. The study wants to find out which approach—stopping the medication a day or two before surgery, or continuing it until the morning of surgery—is safer for your heart during and after the operation.
Some doctors worry that stopping blood pressure medications before surgery could harm the heart, while others worry that continuing them might increase risk. This medication's effect on the heart during cancer surgery hasn't been clearly studied, so researchers need to compare both approaches to figure out what's safest.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to either stop or continue your blood pressure medication before your colorectal cancer surgery. If assigned to stop, you'll receive specific instructions on when to take your last dose (1–2 days before surgery depending on your medication). Blood tests measuring heart enzymes will be taken the day before surgery and on the first and second days after surgery to check for any heart injury. Your doctors will manage your anesthesia and care during surgery without knowing which group you're in.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
Egypt
Phase
Large-scale testing
Sponsor
Kasr El Aini Hospital
Enrollment target
~156 participants
Started
March 2025
Primary completion
January 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 70 Years
Last updated on clinicaltrials.gov in November 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Khaled Sarhan, MD
Kasr El Aini Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.