Plain-English translation of NCT06862375 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing the Mayo Clinic Diet to see if it helps people lose weight more effectively than usual care. You would either get full access to the Mayo Clinic Diet book and app for 12 weeks, or start with standard lifestyle resources and then switch to the diet later. Researchers will measure weight loss, how easy the program is to follow, and how it affects your overall health and quality of life.
Many people struggle to lose weight and keep it off, and doctors want to know whether this particular diet approach works better than general lifestyle advice. Understanding what helps people lose weight and stay committed to healthy changes could help more people succeed.
You likely qualify if…
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You would be randomly assigned to one of two groups for the first 12 weeks. One group gets full access to the Mayo Clinic Diet book and app, while the other group receives standard lifestyle resources. After 12 weeks, the groups switch. Throughout the year, you'll be asked to track your weight and answer questions about your eating, activity, and how you're doing. The study checks in with you at 6 months and 1 year to see how much weight you've lost and how well you've been able to stick with the program.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Enrollment target
~250 participants
Started
March 2025
Primary completion
March 2027
Age range
18 Years – 64 Years
Last updated on clinicaltrials.gov in October 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Family Medicine Research Study Coordinators
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.