Plain-English translation of NCT06863350 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
About one in four people are born with a small opening between two chambers of the heart called a patent foramen ovale (PFO). Researchers have noticed that people with hard-to-treat epilepsy often have this heart opening, and closing it may help reduce seizures. This trial is testing whether a procedure to close the PFO can safely reduce how often seizures happen in adults whose seizures haven't improved with medications.
Many people with epilepsy continue to have seizures even after trying multiple anti-seizure medications, leaving them with few treatment options. Doctors have observed that closing this heart opening in some patients seems to help control seizures, so this trial aims to confirm whether this treatment really works and is safe.
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If you're in the surgery group, you will undergo a procedure to close the hole in your heart using a catheter—a thin tube guided through a blood vessel—which does not require open-heart surgery. You will keep a seizure diary throughout the study and attend follow-up appointments so doctors can monitor your seizures and check that the procedure is working safely. The study will compare your seizure frequency before and after the procedure to see if closing the heart hole helps reduce how often you have seizures.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
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