Plain-English translation of NCT06863402 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether two medications— and —work better together to treat Richter transformation, a serious form of lymphoma that can develop from chronic lymphocytic leukemia. You would take as a daily pill and receive as an infusion once every three weeks. The study wants to see how many people respond well to this combination and whether it is safe.
Richter transformation is a difficult-to-treat condition, and standard chemotherapy may not be suitable for all patients or may stop working over time. This trial exists to explore whether this new combination of two targeted medications could offer hope to people for whom other options are limited.
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You would visit the clinic regularly over about 2 years (or until your disease worsens or side effects become too much). At each visit, you would take as a daily pill at home for 21 days, then receive a 30-minute infusion of in the clinic on the first day of each 3-week cycle. You would have blood tests and imaging scans (CT or PET scans) throughout the study to check how you are responding, and the doctors may perform a heart ultrasound and bone marrow biopsy to monitor your health.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
United States