Plain-English translation of NCT06872463 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
The Karolinska Schizophrenia Project is studying how the brain's immune system may be involved in psychosis — especially in people who are experiencing their first episode. Researchers will use brain imaging, blood tests, and other measurements to understand what happens in the brain when psychosis develops, and whether these changes differ between people with psychosis and healthy people.
Scientists believe the brain's immune system may play a role in psychosis, but this is not yet fully understood. This study aims to identify biological markers early in the disease so that doctors can better understand, diagnose, and eventually treat psychosis more effectively.
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If you have psychosis, you will visit the research center for detailed assessments including clinical interviews, cognitive testing, brain imaging (MRI and PET scans), blood and spinal fluid samples, and other lab tests. You will then be invited back for follow-up visits at 1.5 years and 5 years to repeat some of these measurements. Healthy control participants will complete the same initial assessments and may be invited back at 1.5 years for selected repeat tests.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
Sweden
Sponsor
Karolinska Institutet
Collaborators
Region Stockholm
Enrollment target
~200 participants
Started
January 2011
Primary completion
December 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2025.
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Central contact
Carl M Sellgren, MD, PhD
Karolinska Institutet
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.