Plain-English translation of NCT06874270 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research trial is trying to understand why people with severe obesity respond differently to weight-loss treatment. Researchers will measure how your body burns energy before and after a 24-hour fasting period to identify your unique metabolic type — whether your body conserves energy when you fast or burns it faster. This information may help doctors create a weight-loss plan tailored specifically to how your body works.
People with severe obesity don't all lose weight the same way, even when following the same treatment program. By identifying different metabolic types, doctors hope to match each patient with the approach that will work best for their body, rather than using a one-size-fits-all approach.
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You will have baseline visits where doctors measure your body composition using several techniques (like a body scanner and special equipment to measure how much energy you burn). You'll have your resting metabolic rate measured after an overnight fast, then complete a 24-hour fasting period while wearing a continuous glucose monitor. After fasting, your metabolic rate will be measured again. Based on how much your energy expenditure changes, you'll be placed into a metabolic group that may help guide your future obesity treatment.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
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