Plain-English translation of NCT06874426 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how endoscopic endonasal skull base surgery — a procedure that accesses brain tumors and pituitary gland problems by going through the nose — affects your sense of smell and facial sensations. They'll test your smell and touch before and after surgery, and study tissue samples taken during the operation to understand why some patients experience smell loss after this type of surgery.
After this type of brain surgery, some patients notice they can't smell as well, but doctors don't fully understand how often this happens or why it occurs. This study aims to fill that gap so doctors can better predict and potentially prevent smell loss in future patients.
You likely qualify if…
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Before your scheduled surgery, you'll complete tests of your sense of smell and facial sensation. After your surgery, you'll return for the same tests to see if anything has changed. The research team will also collect a small tissue sample from inside your nose during your surgery — something the surgeon removes anyway to access the area being treated — and study it under a microscope to understand what's happening.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
Belgium
Germany
Netherlands
Universitaire Ziekenhuizen KU Leuven
Enrollment target
~154 participants
Started
March 2025
Primary completion
December 2028
Age range
18 Years – 70 Years
Last updated on clinicaltrials.gov in April 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Julie van Waterschoot
Universitaire Ziekenhuizen KU Leuven
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.