Plain-English translation of NCT06878729 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Coronary Artery Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing two different approaches to treat chronic total occlusions—severely blocked coronary arteries that have been closed for a long time. One approach crosses through the blockage from the front and then re-enters the normal vessel using a special technique (antegrade dissection and re-entry). The other approach crosses the blockage from the back, working against the normal direction of blood flow (retrograde strategy). Researchers want to see which method works faster and achieves better results with fewer complications.
Chronic total occlusions are very difficult to treat and can cause chest pain, shortness of breath, and heart damage. While both techniques are used in clinical practice, doctors aren't sure which one is safer, faster, or leads to better outcomes for patients.
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You will first undergo cardiac imaging (an MRI scan) and blood tests before the procedure to measure heart health. During the procedure, your cardiologist will attempt to open your blocked artery using one of the two techniques—the choice depends on the initial attempt and then random assignment if needed. After the procedure, you will have blood tests at 12-hour intervals for at least 24 hours, a repeat cardiac MRI scan within 5 days, and follow-up questionnaires at 3 months to assess your symptoms and quality of life.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
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