Plain-English translation of NCT06881485 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
After bariatric (weight-loss) surgery, some people regain weight over time. This trial is testing whether using naltrexone/bupropion—a medication that helps reduce hunger and cravings—works better when combined with an intensive diet program and lifestyle coaching, compared to using the medication alone with standard lifestyle support.
Weight regain after bariatric surgery is a common challenge that can reduce the benefits of the surgery. Researchers want to know if pairing this medication with a very structured, short-term diet plan in the first 10 weeks can jumpstart better weight loss and help people maintain their results longer.
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You will visit the hospital at 5 timepoints over one year (at weeks 1, 10, 16, 26, and 52). Half of participants will take the medication plus follow a strict, low-calorie ketogenic diet for the first 10 weeks, then continue the medication with regular lifestyle support for the remaining 42 weeks. The other half will take the medication with standard lifestyle coaching for the full year. Throughout the trial, researchers will track your weight, hunger levels, blood sugar, and how well you tolerate the treatment.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
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