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Take an acid supplement to help manage autoimmune stomach disease | stella

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Recruiting

Testing an acid supplement to help with autoimmune stomach inflammation

Plain-English translation of NCT06881511 on ClinicalTrials.gov ↗ · Source last updated March 2025 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing betaine hydrochloride, an oral supplement that restores stomach acid, in people with autoimmune gastritis—a condition where the immune system damages stomach cells. Your body naturally stops producing enough acid, which causes digestive problems and increases cancer risk. Researchers want to see if this medication can safely lower cancer risk and improve how you digest food and absorb nutrients.

Autoimmune gastritis gradually destroys the cells that make stomach acid, leading to serious complications like anemia, poor nutrient absorption, bacterial overgrowth, and significantly higher risk of stomach cancer. Currently, doctors can only treat the symptoms, not the underlying acid problem. This trial exists to test whether restoring stomach acid with this medication can prevent these dangerous complications.

Do you qualify?

You likely qualify if…

you have been diagnosed with autoimmune gastritis
you have high gastrin levels (above 300 pmol/L) or a history of stomach neuroendocrine tumors or early stomach cancer treated with endoscopic removal
you are between 18 and 80 years old
you are willing and able to sign the informed consent form

You likely don't qualify if…

you are allergic to betaine hydrochloride
you have active peptic ulcers
you have another condition (like gastrinoma) causing high gastrin levels
you are unwilling to sign the informed consent form

What participation looks like

If you join this study, you will be randomly placed in one of two groups: one that takes the medication by mouth and one that receives observation only. Both groups will have regular follow-up visits where your stomach acid levels, gastrin levels, and symptoms will be monitored. The study will track whether the medication safely reduces your cancer risk and improves your digestion over time.

AI-generated summary from trial data · Jun 13, 2026 · Not medical advice

Trial locations(1 site)

China

The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang

Key details

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Enrollment target

~100 participants

Started

January 2025

Primary completion

June 2026

This trial's estimated completion date has passed — the record may not be fully up to date.

Age range

18 Years – 80 Years

Last updated on clinicaltrials.gov in March 2025.

Contact the research team directly

Reach out to the team running this trial. Response times vary — some teams are faster than others.

Central contact

Jianshan Mao, MD, PhD

Second Affiliated Hospital, School of Medicine, Zhejiang University

Interested in joining?

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View full record on ClinicalTrials.gov