Plain-English translation of NCT06883864 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial compares two approaches for people with persistent atrial fibrillation (an irregular heartbeat) and severe mitral regurgitation (leakage in a heart valve). One group receives a catheter ablation procedure—a minimally invasive treatment that uses heat or cold to correct the irregular heartbeat—along with standard heart medications. The other group receives only the standard medications. The goal is to see if the ablation procedure, combined with , helps reduce the valve leakage better than alone.
When the heart beats irregularly over time, it can stretch the mitral valve and cause it to leak badly. This leakage can weaken the heart and cause serious symptoms. Doctors want to know if fixing the irregular heartbeat with ablation can help the valve work better and improve patients' lives more effectively than alone.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to one of two groups. If you are in the ablation group, you will undergo a catheter ablation procedure (a minimally invasive heart procedure) and then receive standard heart medications. If you are in the -only group, you will receive the same heart medications without the procedure. All participants will have heart ultrasounds and other follow-up tests at 3 months and continue with follow-up visits as directed. The study lasts at least several months, with the possibility of continued monitoring in an extension study afterward.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
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