Plain-English translation of NCT06887829 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing low-dose radiation therapy as a potential treatment for knee osteoarthritis pain. Half of the participants will receive actual radiation therapy over two weeks, while the other half will receive a sham treatment (a procedure that looks identical but without radiation). Researchers will track your pain levels for six months to see if the treatment helps.
Knee osteoarthritis affects many older adults and causes persistent pain that is difficult to manage with current treatments. This trial explores whether low-dose radiation therapy, which has shown promise in early research, could offer a new way to reduce pain and improve quality of life for people living with this condition.
You likely qualify if…
You likely don't qualify if…
You would visit Mayo Clinic three times per week for two weeks to receive either the radiation therapy or sham treatment. You'll be asked to complete a pain survey by email weekly for six months. If your pain doesn't improve after the first round, you would return for a second two-week course of the same treatment. The entire study lasts six months from your start date.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Enrollment target
~128 participants
Started
June 2025
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
50 Years – 100 Years
Last updated on clinicaltrials.gov in June 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Family Medicine Research Study Coordinators
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.