Plain-English translation of NCT06888843 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether works better as a single medication or when combined with in older patients with advanced colorectal cancer who have had surgery. The goal is to find the safest and most effective way to give chemotherapy to elderly patients after their surgery, to help prevent their cancer from coming back.
After surgery for advanced colorectal cancer, patients need additional chemotherapy treatment to kill any remaining cancer cells and reduce the risk of recurrence. However, many older patients may not tolerate the standard combination treatments well, so researchers want to find out if a gentler single-drug approach might work just as well while causing fewer side effects.
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You will first go through a 4-week screening period where doctors will do tests to make sure you qualify. Then you will be randomly assigned to receive either alone or combined with , given in 3-week cycles for up to 6 months (or 8 treatment cycles total). After treatment ends, you will have follow-up visits for safety checks for about a month, and then longer-term follow-up for up to 3 years to monitor your health and watch for cancer recurrence.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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