Plain-English translation of NCT06889454 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing how four different approaches affect heart and blood vessel health in women with polycystic ovary syndrome (PCOS). You will either receive lifestyle changes alone, lifestyle changes plus , lifestyle changes plus GLP-1 agonists, or lifestyle changes plus birth control pills. The study will measure your heart function, blood vessel flexibility, and insulin levels before treatment, then again after 6 and 12 months to see which approach works best.
Women with PCOS often have increased risks of heart disease and metabolic problems, but we don't fully understand which treatments best protect the heart and blood vessels. This trial aims to compare treatments head-to-head to find out which one most effectively improves heart health in this population.
You likely qualify if…
You likely don't qualify if…
You will visit the hospital at the start, 6 months, and 12 months. At each visit, you'll receive a glucose drink while doctors perform ultrasound scans of your heart and blood vessels, measure blood pressure, and take blood samples to check your insulin, glucose, and hormone levels. Depending on your assigned group, you'll also either make lifestyle changes, take a daily medication, or both. The entire study lasts one year.
AI-generated summary from trial data · Aug 20, 2026 · Not medical advice
Greece
Sponsor
Attikon Hospital
Enrollment target
~120 participants
Started
February 2024
Primary completion
February 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 45 Years
Sex
Female only
Last updated on clinicaltrials.gov in November 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
VAIA lAMBADIARI, Professor
Attikon Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.