Recruiting

Testing Quick Chemotherapy After Bladder Tumor Surgery

Plain-English translation of NCT06889623 on ClinicalTrials.gov ↗ · Source last updated March 2025 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether cisplatin/gemcitabine chemotherapy given within 24 hours after bladder tumor removal surgery can help prevent cancer from returning. You would receive this medication through an IV infusion shortly after your surgery, followed by the standard follow-up care your doctor recommends. The goal is to see if this approach is safe and effective for people with high-risk bladder cancer.

Bladder cancer often comes back after surgery — up to 78% of patients experience recurrence within five years. While doctors know that a single dose of chemotherapy right after surgery can help, there is not yet strong evidence that this particular medication combination works safely and effectively for people with high-risk disease.

Do you qualify?

You likely qualify if…

you have been diagnosed with high-risk non-muscle-invasive bladder cancer (such as high-grade tumors, recurring tumors, or tumors larger than 3 cm)
you are in generally good overall health and able to commit to 2 years of follow-up care
you have not received chemotherapy, immunotherapy, or radiation therapy before
you have normal or near-normal kidney function and healthy blood cell counts
you are able to receive intravesical therapy (medication placed directly in the bladder) for one year after surgery

You likely don't qualify if…

you have bladder cancer of a type other than urothelial carcinoma
your cancer has already invaded the muscle layer of the bladder or spread to other organs
your tumor could not be completely removed during surgery
you have an active infection or uncontrolled urinary tract infection
you have severely reduced kidney function or dangerously low blood cell counts

What participation looks like

If you enroll, you would have your bladder tumor removed by standard surgery. Within 24 hours, you would receive the chemotherapy medication through an IV infusion. Blood samples would be collected before surgery, after surgery, and after chemotherapy to monitor for residual cancer cells. You would then receive standard follow-up BCG therapy (medicine placed in the bladder) over one year, along with regular check-ups, imaging, and cystoscopy examinations. You would be followed for a total of 2 years to monitor for cancer recurrence.

AI-generated summary from trial data · Jul 18, 2026 · Not medical advice

Trial locations(1 site)

China

Shanghai Changhai Hospital, Shanghai, Shanghai Municipality