Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(354 sites) United States
Clearview Cancer Institute, Huntsville, Alabama Infirmary Cancer Care, Mobile, Alabama The University of Arizona Cancer Center - North Campus, Tucson, Arizona Highlands Oncology Group, Springdale, Arkansas UCLA Hematology/Oncology - Santa Monica, Los Angeles, California Profound Research LLC, Oceanside, California University of California, Irvine (UCI) Health - UC Irvine Medical Center, Orange, California Stanford Cancer Center, Palo Alto, California Kaiser Permanente San Diego Mission Road, San Diego, California BASS Cancer Center, Walnut Creek, California Hartford Hospital (HH), Hartford, Connecticut Sibley Memorial Hospital, Washington D.C., District of Columbia Boca Raton Regional Hospital, Boca Raton, Florida Florida Cancer Specialists - South, Fort Myers, Florida University of Florida - Jacksonville, Jacksonville, Florida Miami Cancer Institute at Baptist Health, Inc., Miami, Florida Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala, Ocala, Florida Florida Cancer Specialists North, St. Petersburg, Florida Comprehensive Hematology Oncology, St. Petersburg, Florida Moffitt Cancer Center, Tampa, Florida Florida Cancer Specialists East, West Palm Beach, Florida Northwestern Memorial Hospital, Chicago, Illinois University of Illinois at Chicago, Chicago, Illinois University of Chicago Medical Center, Chicago, Illinois Captain James A. Lovell Federal Health Care Center, North Chicago, Illinois Springfield Clinic Main Campus, Springfield, Illinois Parkview Research Center at Parkview Regional Medical Center, Fort Wayne, Indiana Franciscan Health, Indianapolis, Indiana Baptist Health Lexington, Lexington, Kentucky Baptist Health Hamburg, Lexington, Kentucky CHI Saint Joseph Cancer Center - East, Lexington, Kentucky Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana Ochsner Health Ochsner Cancer Center - Baton Rouge, Baton Rouge, Louisiana Ochsner Clinic Foundation, New Orleans, Louisiana New England Cancer Specialists, Westbrook, Maine University of Maryland, Baltimore, Maryland Johns Hopkins Bayview Medical Center, Baltimore, Maryland Reliant Medical Group, Worcester, Massachusetts Karmanos Cancer Institute, Detroit, Michigan Missouri Baptist Medical Center, St Louis, Missouri Jefferson Health - Cherry Hill, Cherry Hill, New Jersey Sidney Kimmel Cancer Center - Washington Township, Sewell, New Jersey Columbia University Irving Medical Center, New York, New York Memorial Sloan Kettering Cancer Center, New York, New York Northport VA Medical Center, Northport, New York Aultman Hospital, Canton, Ohio Cleveland Clinic, Cleveland, Ohio The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T, Columbus, Ohio Providence Portland Medical Center, Portland, Oregon Providence St. Vincent Medical Center, Portland, Oregon Kaiser Permanente Interstate Medical Office Central, Portland, Oregon Oregon Health and Science University, Portland, Oregon Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office, Philadelphia, Pennsylvania Jefferson Hospital Northeast, Philadelphia, Pennsylvania AHN Allegheny General Hospital, Pittsburgh, Pennsylvania Medical University of South Carolina, Charleston, South Carolina Lexington Medical Center, West Columbia, South Carolina Tennessee Oncology Chattanooga, Chattanooga, Tennessee University of Tennessee Medical Center, Knoxville, Tennessee Sarah Cannon Research Institute, Nashville, Tennessee SCRI Oncology Partners, Nashville, Tennessee Tennessee Oncology, Nashville, Tennessee The Center for Cancer and Blood Disorders, Fort Worth, Texas Houston Methodist Hospital, Houston, Texas University of Texas MD Anderson Cancer Center, Houston, Texas USO - Texas Oncology - San Antonio, San Antonio, Texas USO - Texas Oncology Gulf Coast, Sugar Land, Texas USO - US Oncology Research Network, The Woodlands, Texas The University of Vermont Medical Center Inc., Burlington, Vermont University of Virginia Health System, Charlottesville, Virginia VCU Health Adult Outpatient Pavillion, Richmond, Virginia Swedish Cancer Institute - Edmonds, Edmonds, Washington Swedish Medical Center, Seattle, Washington Cancer Care Northwest - Vercler, Spokane Valley, Washington Northwest Cancer Specialists PC, Vancouver, Washington University Hospital and UW Health Clinics, Madison, Wisconsin Medical College of Wisconsin, Milwaukee, Wisconsin Australia
Icon Cancer Centre Wesley, Auchenflower Sunshine Coast University Hospital, Birtinya Austin Health, Heidelberg ICON Cancer Centre - Kurralta Park, Kurralta Park Tamworth Hospital, North Tamworth Sir Charles Gairdner Hospital, Perth Goulburn Valley Health, Shepparton Latrobe Regional Health, Traralgon Austria
Medizinische Universität Graz, Graz Ordensklinikum Linz GmbH Elisabethinen, Linz Klinik Floridsdorf, Vienna Belgium
CHIREC - site delta, Auderghem Antwerp University Hospital, Edegem Brazil
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos CTO - Centro de Tratamento Oncológico, Belém Oncocentro de Minas Gerais, Belo Horizonte Hospital Tacchini, Bento Gonçalves Centro de Pesquisa Sao Lucas, Campinas Centro de Pesquisa Clínica do Instituto do Câncer do Ceará, Fortaleza Hospital de Cancer de Londrina, Londrina Liga Norte Riograndense Contra o Câncer, Natal Hospital São Lucas da PUCRS, Porto Alegre Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA, Rio de Janeiro Instituto D'Or Pesquisa e Ensino, Rio de Janeiro Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo Hospital Sírio Libanês, São Paulo
Chile
Centro de Oncología de Precisión, Santiago China
Anyang Cancer Hospital, Anyang Cancer Hospital Chinese Academy of Medical Science, Beijing China-Japan Friendship Hospital, Beijing Peking University People's Hospital, Beijing Beijing Cancer hospital, Beijing Jilin Cancer Hospital, Changchun Xiangya Hospital Central South University, Changsha Xiangya Hospital Central South University, Changsha Hunan Cancer Hospital, Changsha Hunan Cancer Hospital, Changsha The Third People's Hospital of Chengdu (CDTPH), Chengdu Sichuan Cancer hospital, Chengdu West China Hospital, Sichuan University, Chengdu Czechia
Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava Fakultni nemocnice Bulovka, Prague France
Hospices Civils de Lyon - Hopital Louis Pradel, Bron Chu Grenoble Alpes, La Tronche Centre Leon Berard, Lyon Cedex08 Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille Centre Antoine-Lacassagne, Nice Groupe hospitalier Paris saint Joseph, Paris Hôpital Européen Georges Pompidou, Paris CHU Bordeaux Haut-Leveque, Pessac Centre Hospitalier Universitaire de Poitiers, Poitiers Institut Jean Godinot, Reims Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, Rennes Institut de Cancérologie de l'Ouest, Saint-Herblain Germany
Vivantes Klinikum im Friedrichshain - Landsberger Allee, Berlin Evangelische Lungenklinik Berlin, Berlin Charité Campus Virchow-Klinikum, Berlin DRK Kliniken Berlin Mitte, Berlin Klinikum Chemnitz, Chemnitz MV-Zentrum für Onkologie und Hämatologie, Cologne Klinikum Köln-Merheim, Cologne Onkologiezentrum Donauwörth, Donauwörth HELIOS Klinikum Erfurt, Erfurt Asklepios Fachkliniken München-Gauting, Gauting Franziskus-Hospital Harderberg, Georgsmarienhütte LungenClinic Grosshansdorf, Großhansdorf Krankenhaus Martha-Maria Halle-Dölau, Halle Greece
Agios Savvas Regional Cancer Hospital, Athens Errikos Dunant Hospital Center, Athens Thoracic General Hospital of Athens "I Sotiria", Athens University General Hospital of Heraklion, Heraklion University General Hospital of Larissa, Larissa University Hospital of Patras, Pátrai Agios Loukas Clinic, Thessaloniki European Interbalkan Medical Center, Thessaloniki Hungary
Országos Onkológiai Intézet, Budapest Budapesti Uzsoki Utcai Kórház, Budapest Farkasgyepui Tudogyogyintezet, Farkasgyepű India
Hemato Oncology Clinic, Ahmedabad Galaxy Superspeciality Hospital, Aurangabad Rajiv Gandhi Government General Hospital, Chennai Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai Thangam Cancer Center - Namakkal, Namakkal Savera Cancer & Multi Speciality Hospital, Patna Deenanath Mangeshkar Hospital & Research Centre, Pune Medipoint Hospitals Pvt. Ltd., Pune Malabar Cancer Centre - Thalassery, Thalassery Regional Cancer Centre - Thiruvananthapuram, Thiruvananthapuram Pacific Medical College & Hospital, Udaipur Tata Memorial Centre - Homi Bhabha Cancer Hospital, Varanasi Israel
Rambam Health Care Campus, Haifa Shaare Zedek Medical Center, Jerusalem Meir Medical Center, Kfar Saba Sheba Medical Center, Ramat Gan Italy
Instituto Tumori Giovanni Paolo II, Bari Policlinico "G. Rodolico", Catania Ospedale San Martino, Genova Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola ASST Grande Ospedale Metropolitano Niguarda, Milan Ospedale San Gerardo-ASST Monza, Monza Azienda Ospedaliera Dei Colli, Naples Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano Istituto Nazionale Tumori Regina Elena, Rome Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona Japan
Juntendo University Hospital, Bunkyō City Tokyo Metropolitan Komagome Hospital, Bunkyō City Kyushu University Hospital, Fukuoka Saitama Medical University International Medical Center, Hidaka Himeji Medical Center, Himeji Kansai Medical University Hospital, Hirakata Kanazawa University Hospital, Kanazawa National Cancer Center Hospital East, Kashiwa The Cancer Institute Hospital of JFCR, Kōtō City University Hospital,Kyoto Prefectural University of Medicine, Kyoto Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun Aichi Cancer Center Hospital, Nagoya Miyagi Cancer Center, Natori Netherlands
Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL), Amsterdam Amsterdam UMC, locatie VUmc, Amsterdam Amphia Ziekenhuis, locatie Breda Molengracht, Breda Ziekenhuis St. Jansdal, Harderwijk St. Antonius Ziekenhuis, locatie Utrecht, Utrecht Isala, locatie Zwolle, Zwolle Norway
Sorlandet Sykehus Arendal, Arendal Haukeland Universitetssjukehus, Bergen Drammen Sykehus, Vestre Viken HF, Drammen Sykehuset Innlandet HF Gjøvik, Gjøvik Oslo universitetssykehus, Radiumhospitalet, Oslo Poland
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej, Kielce Wielkopolskie Centrum Pulmonologii i Torakochirurgii, Poznan Portugal
Centro Hospitalar E Universitário De Coimbra, Coimbra Hospital da Luz Lisboa, Lisbon Hospital CUF Porto, Porto Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto Romania
SC Memorial Healthcare International SRL, Bucharest Institutul Oncologic, Cluj-Napoca Ovidius Clinical Hospital OCH, Ovidiu Slovakia
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica, Banská Bystrica Univerzitná nemocnica Bratislava - Nemocnica Ružinov, Bratislava Vychodoslovensky Onkologicky ustav a.s., Košice South Korea
The Catholic University of Korea, Incheon St. Mary's Hospital, Bupyeong-gu Pusan National University Hospital, Busan Chungbuk National University Hospital, Cheongju-si Keimyung University Dongsan Hospital, Daegu Kyungpook National University Chilgok Hospital, Deagu Gangnam Severance Hospital, Yonsei University Health System, Gangnam-gu National Cancer Center, Goyang-si Chonnam National University Hwasun Hospital, Hwasun-gun Yeungnam Univeristy Medical Center, Nam-gu Seoul National University Bundang Hospital, Seongnam The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul Severance Hospital, Yonsei University Health System, Seoul Konkuk University Medical Center, Seoul Spain
Hospital Infanta Cristina, Badajoz Parc de Salut Mar - Hospital del Mar, Barcelona Hospital Universitari Vall d'Hebron, Barcelona Hospital Clínic de Barcelona, Barcelona Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet Hospital Jerez de la Frontera, Jerez de la Frontera Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria Hospital General Universitario Gregorio Marañon, Madrid Hospital Universitario Ramón y Cajal, Madrid Hospital Universitario 12 de Octubre, Madrid H.R.U Málaga - Hospital General, Málaga Hospital Universitari Son Espases, Palma Complejo Hospitalario de Navarra, Pamplona Sweden
Sahlgrenska Universitetssjukhuset, Gothenburg Switzerland
Kantonsspital Baden, Baden HFR Fribourg - Hôpital Cantonal, Fribourg Kouros Moccia Oncologia, Locarno Taiwan
Changhua Christian Hospital, Changhua County Buddhist Dalin Tzu Chi General Hospital, Chiayi City National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region, Douliu Hualien Tzu Chi Medical Center, Hualien City Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City E-Da hospital, Kaohsiung City Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist Far Eastern Memorial Hospital, New Taipei City New Taipei Municipal TuCheng Hospital, New Taipei City Chung Shan Medical University Hospital, Taichung Taichung Veterans General Hospital, Taichung National Cheng Kung University Hospital, Tainan Chi Mei Medical Center, Tainan
Turkey (Türkiye)
Baskent University Dr. Turgut Noyan Research and Training Center, Adana Adana City Hospital, Adana Sakarya University School of Medicine, Adapazarı University of Health Sciences,Gulhane School of Medicine, Ankara Antalya Egitim ve Arastırma Hastanesi, Antalya Trakya University, Edirne Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi, Gaziantep İ.A.Ü VM Medical Park Florya Hastanesi, Istanbul Izmir Atatürk Training and Research Hospital, Izmir Marmara Universitesi Pendik Egitim Arastirma Hastanesi, Pendik Samsun Medical Park Hastanesi, Samsun United Kingdom
Heartlands Hospital, Birmingham University Hospitals Sussex NHS Foundation Trust, East Sussex Huddersfield Royal Infirmary, Huddersfield Royal Marsden Hospital (Sutton), London Royal Marsden Hospital (Chelsea), London The Christie NHS Foundation Trust, Manchester Key details Sponsor
Eli Lilly and Company
Enrollment target
~700 participants
Primary completion
May 2029
Hospital Santa Catarina - Paulista, São Paulo
Centro Paulista de Oncologia Clínica, São Paulo Instituto D'Or de Pesquisa e Ensino (IDOR), São Paulo The Second Affiliated Hospital Chongqing Medical University, Chongqing
The First People's Hospital of Foshan, Foshan Guangdong Provincial People's Hospital, Guangzhou The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Zhejiang Provincial People's Hospital, Hangzhou Zhejiang Cancer Hospital, Hangzhou Zhejiang Cancer Hospital, Hangzhou The Second Affiliated hospital of Zhejiang University school of medicine, Hangzhou Harbin Medical University Cancer Hospital, Harbin Jinan Central Hospital, Jinan Shandong Cancer Hospital, Jinan Taizhou Hospital of Zhejiang Province, Linhai Liuzhou People's Hospital, Liuchow The First Affiliated Hospital of Henan University of Science &Technology, Luoyang Guangxi Medical University Affiliated Tumor Hospital, Nanning The Second People's Hospital of Neijiang, Neijiang Shanghai Chest Hospital, Shanghai Fudan University Shanghai Cancer Center, Shanghai Cancer Hospital of Shantou University Medical College, Shantou ShenZhen People's Hospital, Shenzhen Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center, Shenzhen The First Affiliated Hospital of Soochow University, Suzhou Tianjin Medical University Cancer Institute & Hospital, Tianjin Tianjin Medical University Cancer Institute & Hospital, Tianjin Tongji Hospital Tongji Medical,Science & Technology, Wuhan Hubei Cancer Hospital, Wuhan The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Zhongshan Peoples Hospital, Zhongshan ZhuZhou Central Hospital, Zhuzhou CHU de Toulouse - Hopital Larrey, Toulouse
Hôpital Robert Schuman, Vantoux Gustave Roussy, Villejuif Asklepios Klinik Harburg, Hamburg
Thoraxklinik-Heidelberg gGmbH, Heidelberg Evangelisches Krankenhaus Herne - Eickel, Herne St. Elisabeth-Krankenhaus Leipzig, Leipzig Klinikum Nürnberg Nord, Nuremberg Robert Bosch Krankenhaus GmbH, Stuttgart Universitaetsklinikum Tuebingen, Tübingen Niigata Cancer Center Hospital, Niigata
Kindai University Hospital- Osakasayama Campus, Sakai NHO Kinki Chuo Chest Medical Center, Sakai Hokkaido University Hospital, Sapporo Wakayama Medical University Hospital, Wakayama Kanagawa Cardiovascular and Respiratory Center, Yokohama Kanagawa cancer center, Yokohama Tottori University Hospital, Yonago Asan Medical Center, Seoul Samsung Medical Center, Seoul The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul Korea University Guro Hospital, Seoul The Catholic University Of Korea St. Vincent's Hospital, Suwon Pusan National University Yangsan Hospital, Yangsan Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón
CHUS - Hospital Clinico Universitario, Santiago de Compostela Hospital Universitario Virgen Del Rocio, Seville Hospital Clinico de Valencia, Valencia Hospital Clínico Universitario Lozano Blesa, Zaragoza Chi Mei Hospital - Liouying Branch, Tainan
National Taiwan University Hospital, Taipei National Taiwan University Cancer Center (NTUCC), Taipei Taipei Veterans General Hospital, Taipei Chang Gung Medical Foundation-Linkou Branch, Taoyuan District