Plain-English translation of NCT06891326 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing transcranial alternating current stimulation (tACS) — a non-invasive treatment that uses gentle electrical currents applied to the scalp to help reduce depression. Unlike more invasive treatments, this technique is designed to be safer and more affordable. Researchers want to understand whether tACS truly works for depression and how it affects brain activity.
While this treatment shows promise for depression, past studies have given mixed and incomplete results. This larger, well-designed trial aims to get clearer answers about whether this treatment is truly effective and safe for patients who need new options.
You likely qualify if…
You likely don't qualify if…
You would visit the clinic twice per week for four weeks, receiving 40-minute sessions of gentle electrical stimulation applied to your scalp through electrodes. Half of participants will receive the active treatment, and half will receive a placebo (sham) stimulation — neither you nor the research team will know which group you're in. You'll have check-in visits at 2, 4, 6, and 8 weeks, where you'll complete questionnaires about your mood and quality of life, and some visits will include brain scans or brain activity recordings.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
China
Sponsor
Ruijin Hospital
Collaborators
Shanghai Mental Health Center, Shandong Mental Health Center
Enrollment target
~72 participants
Started
October 2024
Primary completion
September 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in March 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Yunhao Wu
Ruijin Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.