Brain Activity Patterns in Depression, Bipolar Disorder, and Memory Changes

Plain-English translation of NCT06897670 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

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What is this trial?

This research study uses a special, non-invasive brain imaging technique called functional near-infrared spectroscopy to measure blood flow patterns in the brains of people with major depression, bipolar disorder, or mild cognitive impairment. Researchers will compare these brain patterns across different groups and see how they relate to symptom severity. The study also measures heart rate and blood oxygen levels to understand how your nervous system and brain activity are connected.

Depression, bipolar disorder, and memory problems affect millions of people, but doctors still don't fully understand the underlying brain changes that cause these conditions. By identifying specific brain activity patterns, this research could help doctors diagnose these conditions earlier and develop better treatments in the future.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have a confirmed diagnosis of major depression, bipolar disorder, or mild cognitive impairment (or you are a healthy control with no psychiatric or cognitive conditions)
your condition is stable and not requiring emergency treatment
you have the ability to understand and complete study tasks, including clinical assessments
you can provide written informed consent

You likely don't qualify if…

you have active psychotic symptoms or a substance use disorder (other than nicotine) in the past year
you have a severe or unstable medical condition that could interfere with the study
you have an active neurological condition such as seizure disorder, traumatic brain injury, or recent stroke
you are pregnant
you had brain stimulation therapy (for depression groups) within the past 3 months

What participation looks like

If you enroll, you will visit the research center for assessments that include brain imaging using a safe, non-invasive scanner that measures blood flow in your brain. You'll also complete standard clinical interviews and questionnaires about your mood or memory, and wear sensors to measure your heart rate and blood oxygen levels. The study involves observation and testing only — no medications or invasive procedures — and researchers will compare your results with other participants in your group.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(1 site)

United States

Mayo Clinic, Rochester, Minnesota