Adding a Pre-Surgery Treatment to Surgery for Large Liver Cancer

This trial is testing whether giving patients a pre-surgery treatment called TACE (a minimally invasive procedure that delivers chemotherapy directly to the tumor) before surgery helps prevent liver cancer from coming back. Researchers want to compare two groups: one that receives TACE before surgery, and one that receives surgery alone. The trial involves 326 patients with very large liver tumors (larger than 10 centimeters) to see if this combination approach leads to better long-term outcomes.

Large liver cancers have a very high chance of coming back even after surgery is successful—up to 70% of patients experience recurrence within two years. This medication aims to shrink the tumor before surgery and reduce the risk of cancer returning, potentially improving survival and quality of life.