New drug combination injected into the brain to treat advanced lung cancer

This trial is testing whether a combination of two medications — pemetrexed and nivolumab — can safely and effectively treat a serious condition where lung cancer has spread to the protective lining surrounding the brain and spinal cord. Instead of taking these medications by mouth or through an IV, they will be injected directly into the fluid around your brain using a small device called an Ommaya reservoir. The study wants to learn whether this approach can help control the cancer in people who haven't responded well to other treatments.

When lung cancer spreads to the lining of the brain, it is very difficult to treat because most medications cannot reach the brain in high enough amounts. This trial is testing a new approach — delivering the medication directly where the cancer is — to see if it can work better than current options for people whose cancer has stopped responding to standard treatments.