Plain-English translation of NCT06902285 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether Magnesium-L-Threonate, a form of magnesium that may help the brain, can improve sleep quality and reduce pain after knee or hip replacement surgery. Many people struggle with sleep and discomfort in the weeks following joint replacement, and this study wants to see if this medication can help with both issues. You would receive either the active medication or a placebo (a look-alike pill with no active ingredient) for up to 6 weeks after your surgery.
After joint replacement surgery, patients often have difficulty sleeping due to pain and discomfort, which can slow down recovery. This study is exploring whether this medication might be a safe and effective way to help people sleep better during this critical healing period.
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If you join this study, you would undergo your joint replacement surgery as planned, and then be randomly assigned to receive either the magnesium supplement or a placebo for up to 6 weeks during your recovery. You would take the medication or placebo by mouth during this period and participate in follow-up visits where the research team would ask you about your sleep quality and pain levels to see if the treatment made a difference.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
University of Miami
Enrollment target
~64 participants
Started
April 2025
Primary completion
July 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Victor H Hernandez, MD
University of Miami
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.