Testing a cholesterol medication to prevent liver disease recurrence after transplant

This trial is testing whether fenofibrate, a medication commonly used to treat high cholesterol, can help prevent primary sclerosing cholangitis from coming back after a liver transplant. The disease tends to recur in about 1 in 5 patients within five years, which can damage the new liver. Researchers believe this medication may protect the new liver by reducing harmful bile acids that damage the bile ducts.

Right now, there is no proven medication to prevent this disease from returning after transplant, and when it does come back, it often leads to serious complications and liver failure. This medication has shown promise in earlier studies, and this trial aims to determine whether it can actually prevent the disease from returning and protect long-term transplant survival.