Understanding brain and heart injury after brain bleeding

Plain-English translation of NCT06906432 on ClinicalTrials.gov ↗ · Source last updated April 2025 · Translation generated June 2026 · How we translate trials

What is this trial?

When someone has a serious brain bleed (intracranial hemorrhage), it can sometimes injure the heart as well — a condition doctors call cerebrocardiac syndrome. This study wants to understand why this happens and how to predict and prevent these heart injuries. Researchers will collect blood samples, medical information, and imaging scans from patients with brain bleeds to discover the biological mechanisms that cause both brain and heart damage.

Brain bleeds have high death rates and can cause serious long-term problems. Doctors have noticed that patients often develop unexpected heart problems after a brain bleed, but they don't fully understand why this happens. By studying the biological changes in patients' blood and imaging their brains and hearts over time, researchers hope to find better ways to diagnose, prevent, and treat these dangerous complications.

Do you qualify?

You likely qualify if…

you are 18 years old or older
you have been diagnosed with a brain bleed confirmed by CT, MRI, or similar imaging within the past 48 hours
you are able to give informed consent or have a legal representative who can consent on your behalf

You likely don't qualify if…

you have a history of serious heart problems (like a previous heart attack or heart failure) unless they are stable and well-controlled
you have had heart surgery, stent placement, or other major heart procedures in the past 6 months
you have a brain tumor, had a stroke in the past 3 months, or have a previous brain injury that could affect the study results
you have active cancer, a severe infection, or have had any surgery in the past 3 months
your doctor believes it would be unsafe or impractical for you to participate

What participation looks like

You will receive your standard medical care for the brain bleed, and researchers will also collect additional information about you. This includes blood samples for laboratory testing, detailed imaging scans of your brain and heart, and careful tracking of your health status over time. The study team will review your medical records and ask questions to understand any heart or brain complications that develop. You'll be monitored as part of a group of about 1,000 patients to help doctors understand these injury patterns.

Understanding brain and heart injury after brain bleeding

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)